Global Health: After Measles Success, Rwanda to Get Rubella Vaccine


Rwanda has been so successful at fighting measles that next month it will be the first country to get donor support to move to the next stage — fighting rubella too.


On March 11, it will hold a nationwide three-day vaccination campaign with a combined measles-rubella vaccine, hoping to reach nearly five million children up to age 14. It will then integrate the dual vaccine into its national health service.


Rwanda can do so “because they’ve done such a good job on measles,” said Christine McNab, a spokeswoman for the Measles and Rubella Initiative. M.R.I. helped pay for previous vaccination campaigns in the country and the GAVI Alliance is helping to finance the upcoming one.


Rubella, also called German measles, causes a rash that is very similar to the measles rash, making it hard for health workers to tell the difference.


Rubella is generally mild, even in children, but in pregnant women, it can kill the fetus or cause serious birth defects, including blindness, deafness, mental retardation and chronic heart damage.


Ms. McNab said that Rwanda had proved that it can suppress measles and identify rubella, and it would benefit from the newer, more expensive vaccine.


The dual vaccine costs twice as much — 52 cents a dose at Unicef prices, compared with 24 cents for measles alone. (The MMR vaccine that American children get, which also contains a vaccine against mumps, costs Unicef $1.)


More than 90 percent of Rwandan children now are vaccinated twice against measles, and cases have been near zero since 2007.


The tiny country, which was convulsed by Hutu-Tutsi genocide in 1994, is now leading the way in Africa in delivering medical care to its citizens, Ms. McNab said. Three years ago, it was the first African country to introduce shots against human papilloma virus, or HPV, which causes cervical cancer.


In wealthy countries, measles kills a small number of children — usually those whose parents decline vaccination. But in poor countries, measles is a major killer of malnourished infants. Around the world, the initiative estimates, about 158,000 children die of it each year, or about 430 a day.


Every year, an estimated 112,000 children, mostly in Africa, South Asia and the Pacific islands, are born with handicaps caused by their mothers’ rubella infection.


Thanks in part to the initiative — which until last year was known just as the Measles Initiative — measles deaths among children have declined 71 percent since 2000. The initiative is a partnership of many health agencies, vaccine companies, donors and others, but is led by the American Red Cross, the United Nations Foundation, the Centers for Disease Control and Prevention, Unicef and the World Health Organization.


This article has been revised to reflect the following correction:

Correction: February 27, 2013

An earlier version of this article misstated the source of the vaccine and some financing for the campaign. The vaccine and financing is being provided by the GAVI Alliance, not the Measles and Rubella Initiative.




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TED 2013: Sergey Brin talks Google Glass

























































































Chris Anderson, Sergey Brin


TED's Chris Anderson, left, and Google's Sergey Brin discuss Google Glass at TED 2013.
(James Duncan Davidson / TED)





































































There's no question about what the ultimate accessory was this week at TED 2013 in Long Beach:


Google Glass. 


QUIZ: How much do you know about Google?





In conference hotels, parties and at the conference itself, random people could be spotted wearing the ultimate must-have-but-incredibly-scarce gadget. 


On Wednesday, Google's Sergey Brin took to the stage at TED 2013 wearing his pair to discuss his, ahem, vision for Google Glass. His appearance came on the day when applications were due in a contest to win the right to buy one of the $1,500 devices.


TED released official photos from the session. According to the TED blog, Brin said: 


"When we started Google 15 years ago, my vision was that information would come to you as you need it. You wouldn't have to search query at all."


But, he argued, the smartphone is antisocial, because you look away from people. From the TED blog: "Is this the way you're meant to interact with other people? It's kind of emasculating. Is this what you're meant to do with your body?"


Naturally, TEDsters shared their awe on Twitter:





ALSO:


Google in talks with Warby Parker for its glasses [Video chat]


Google's Android chief says company doesn't need retail stores


Google Glass application period ends today: Here's how to enter 


twitter.com/@obrien
































































































































































































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Gaza militants break cease-fire with rocket attack into Israel

























































































Gaza attack


Israeli police remove the remains of a rocket in the town of Ashkelon.
(EPA / February 26, 2013)





































































JERUSALEM -- Palestinian unrest spread Tuesday to the Gaza Strip, where militants fired a rocket into southern Israel, shattering one of the longest periods of quiet along that border in recent memory.


It was the first rocket fired since the signing of a November cease-fire agreement between Israel and the Palestinian militant group Hamas, ending their eight-day clash.


The morning attack came as Palestinians in the West Bank protest the death of 30-year-old Arafat Jaradat, a gas station attendant who died suddenly in Israeli custody after being arrested for throwing rocks at an Israeli settler.





Palestinians claim Jaradat was tortured to death. Israelis say the exact cause of his Feb. 23 death has not yet been determined.


The Grad rocket fired early Tuesday landed in an open area near the Israeli city of Ashkelon, causing no damage or injuries.


ALSO:


Palestinians at funeral protest death of prisoner


Syria ready to talk to rebels, foreign minister says


U.S. military denies abducting, killing civilians in Afghan province

































































































































































































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was called on */
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var makeURLS = function (link, message){
/* Here we construct the Tweet URL using an array, with values passed to the function */
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fbURL = fbConstruct.join(''),

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Mindy McCready's funeral held in southwest Florida


FORT MYERS, Fla. (AP) — As her music played in the background, country music star Mindy McCready was remembered Tuesday by friends and family as a fun and talented singer who also "wanted to be healed" from her past.


About 200 friends and family gathered in the 37-year-old singer's Florida hometown of Fort Myers. A large screen behind the altar of Crossroads Baptist Church was filled with her images and her portrait stood nearby.


"Our Mindy was so tired. She felt helpless," said McCready's mother, Gayle Inge. "She was in her darkest moment and she was hurt by so many allegations. She was too emotional to understand."


McCready, whose real name was Malinda Gayle McCready, committed suicide Feb. 17 at her home in Arkansas, days after leaving a court-ordered substance abuse treatment program. The mother of two died from a single gunshot to the head about a month after her longtime boyfriend David Wilson's death, also thought to be suicide, in the same place.


Inge acknowledged that her daughter had faced many battles but now: "Her spirit found healing on the other side."


McCready's personal problems started in 2004 and included a custody battle with her mother over one of her sons. She was briefly hospitalized in 2010 after police responded to an overdose call to a home her mother owned in North Fort Myers, Fla., and she later appeared on "Celebrity Rehab with Dr. Drew," where she declared herself clean from drugs.


McCready's family declined to address any custody issue at the funeral.


"She wanted them to know that nothing, not even death, could separate her from them," Gayle Inge said of McCready's two sons, Zander Ryan and Zayne Christopher. "She's healed. She's no longer sick," she added, referring to what she told McCready's sons.


A separate funeral organized by her friends and the music community is tentatively scheduled for March 6 in Nashville, Tenn.


McCready's stepfather, brothers and cousin also shared their fondest — and often funny — memories of McCready.


"You all know I grew up coming from a broken home," said brother Timothy McCready, wiping away tears. "It makes your brothers and sisters really important to you. We used to joke about how she raised us...we raised each other, all of us. And she probably got us all in a lot more trouble than she got us out of," he later joked about his sister.


"I just know that Mindy is on vacacioun where she is," said younger brother Skylar Phelan, referring to how McCready often used the Latin word for "vacation" to get out of chores.


McCready grew up in Fort Myers, where she took private vocal lessons and later sang in karaoke bars.


Family friend Julie Ende-Killion remembers the day when McCready won her first award for "Ten Thousand Angels."


"And I remember her coming out of the trailer," she recalled. "I think she was in Kenny Chesney's trailer because she didn't even have her own dressing room at that time. Nashville is a pretty cool place. She made her mark on it."


McCready arrived in Nashville in 1994 and hit the top of the country charts before her personal problems sidetracked her career.


In 1996, her "Guys Do It All the Time" hit No. 1. Her other hits included "Ten Thousand Angels," which her stepfather sang during the funeral.


"She's our special angel," said Michael Inge. "She sang a song years ago about 'Ten Thousand Angels' watching over her and now she is in the presence of all those 10 thousand angels," Michael Inge said.


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Advanced Breast Cancer May Be Rising Among Young Women, Study Finds


The incidence of advanced breast cancer among younger women, ages 25 to 39, may have increased slightly over the last three decades, according to a study released Tuesday.


But more research is needed to verify the finding, which was based on an analysis of statistics, the study’s authors said. They do not know what may have caused the apparent increase.


Some outside experts questioned whether the increase was real, and expressed concerns that the report would frighten women needlessly.


The study, published in The Journal of the American Medical Association, found that advanced cases climbed to 2.9 per 100,000 younger women in 2009, from 1.53 per 100,000 women in 1976 — an increase of 1.37 cases per 100,000 women in 34 years. The totals were about 250 such cases per year in the mid-1970s, and more than 800 per year in 2009.


Though small, the increase was statistically significant, and the researchers said it was worrisome because it involved cancer that had already spread to organs like the liver or lungs by the time it was diagnosed, which greatly diminishes the odds of survival.


For now, the only advice the researchers can offer to young women is to see a doctor quickly if they notice lumps, pain or other changes in the breast, and not to assume that they cannot have breast cancer because they are young and healthy, or have no family history of the disease.


“Breast cancer can and does occur in younger women,” said Dr. Rebecca H. Johnson, the first author of the study and medical director of the adolescent and young adult oncology program at Seattle Children’s Hospital.


But Dr. Johnson noted that there is no evidence that screening helps younger women who have an average risk for the disease and no symptoms. We’re certainly not advocating that young women get mammography at an earlier age than is generally specified,” she said.


Expert groups differ about when screening should begin; some say at age 40, others 50.


Breast cancer is not common in younger women; only 1.8 percent of all cases are diagnosed in women from 20 to 34, and 10 percent in women from 35 to 44. However, when it does occur, the disease tends to be more deadly in younger women than in older ones. Researchers are not sure why.


The researchers analyzed data from SEER, a program run by the National Cancer Institute to collect cancer statistics on 28 percent of the population of the United States. The study also used data from the past when SEER was smaller.


The study is based on information from 936,497 women who had breast cancer from 1976 to 2009. Of those, 53,502 were 25 to 39 years old, including 3,438 who had advanced breast cancer, also called metastatic or distant disease.


Younger women were the only ones in whom metastatic disease seemed to have increased, the researchers found.


Dr. Archie Bleyer, a clinical research professor in radiation medicine at the Knight Cancer Institute at the Oregon Health and Science University in Portland who helped write the study, said scientists needed to verify the increase in advanced breast cancer in young women in the United States and find out whether it is occurring in other developed Western countries. “This is the first report of this kind,” he said, adding that researchers had already asked colleagues in Canada to analyze data there.


“We need this to be sure ourselves about this potentially concerning, almost alarming trend,” Dr. Bleyer said. “Then and only then are we really worried about what is the cause, because we’ve got to be sure it’s real.”


Dr. Johnson said her own experience led her to look into the statistics on the disease in young women. She had breast cancer when she was 27; she is now 44. Over the years, friends and colleagues often referred young women with the disease to her for advice.


“It just struck me how many of those people there were,” she said.


Dr. Donald A. Berry, an expert on breast-cancer data and a professor of biostatistics at the University of Texas’ M.D. Anderson Cancer Center in Houston, said he was dubious about the finding, even though it was statistically significant, because the size of the apparent increase was so small — 1.37 cases per 100,000 women, over the course of 30 years.


More screening and more precise tests to identify the stage of cancer at the time of diagnosis might account for the increase, he said.


“Not many women aged 25 to 39 get screened, but some do, but it only takes a few to account for a notable increase from one in 100,000,” Dr. Berry said.


Dr. Silvia C. Formenti, a breast cancer expert and the chairwoman of radiation oncology at New York University Langone Medical Center, questioned the study in part because although it found an increased incidence of advanced disease, it did not find the accompanying increase in deaths that would be expected.


A spokeswoman for an advocacy group for young women with breast cancer, Young Survival Coalition, said the organization also wondered whether improved diagnostic and staging tests might explain all or part of the increase.


“We’re looking at this data with caution,” said the spokeswoman, Michelle Esser. “We don’t want to invite panic or alarm.”


She said it was important to note that the findings applied only to women who had metastatic disease at the time of diagnosis, and did not imply that women who already had early-stage cancer faced an increased risk of advanced disease.


Dr. J. Leonard Lichtenfeld, deputy chief medical officer of the American Cancer Society, said he and an epidemiologist for the society thought the increase was real.


“We want to make sure this is not oversold or that people suddenly get very frightened that we have a huge problem,” Dr. Lichtenfeld said. “We don’t. But we are concerned that over time, we might have a more serious problem than we have today.”


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Latest signs of housing rebound send stocks higher









The latest signs of a rebound in housing are sending stocks sharply higher on Wall Street.

The Dow Jones industrial average jumped nearly 116 points to end at 13,900 Tuesday, led by a 6 percent surge in Home Depot. The country's biggest home improvement store chain reported a big increase in earnings.

In another sign that the housing market was gaining steam, the government reported that sales of new homes jumped 16 percent last month to the highest level since July 2008.

That sent the stocks of homebuilders higher. Hovnanian jumped 11 percent.

The Standard & Poor's 500 rose nine points to 1,496. The Nasdaq rose 13 to 3,129.

Two stocks rose for every one that fell on the New York Stock Exchange. Volume was average at 3.8 billion shares.

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Oscars 2013: An 'Argo' night at Academy Awards









For the second straight year, the movie business fell for itself.


"Argo" — in which a Hollywood producer and makeup artist help engineer the rescue of six Americans from Iran — won the top prize at the 85th Academy Awards, one year after the silent film story "The Artist" took the best picture Oscar.


"I never thought I'd be back here. And I am," producer-director Ben Affleck said in accepting the best picture trophy Sunday night, 15 years after he won an original screenplay Oscar for "Good Will Hunting" and then saw his career fall into a tailspin that included "Gigli" and "Daredevil."








FULL COVERAGE: Oscars 2013 | Winners


"It doesn't matter how you get knocked down in life. That's going to happen," said Affleck, who wasn't nominated for directing "Argo," one of nine films in the best picture race. "All that matters is that you've got to get up."


"Argo," which became the first movie to win best picture without its director being nominated since 1989's "Driving Miss Daisy," collected two other Academy Awards, for editing and adapted screenplay. But it was not the evening's most recognized film: That honor went to Ang Lee's "Life of Pi," which won four Oscars — for directing, visual effects, cinematography and score.


"Thank you, movie god," said Lee, whose movie came into the evening with 11 nominations, one behind Steven Spielberg's "Lincoln." The film about the 16th president helped Daniel Day-Lewis make movie history, as he became the only man to ever win three lead actor statuettes. "Lincoln" won one other prize, for production design.


The song-and-dance heavy ceremony, hosted by Seth MacFarlane, hewed closely to a traditional awards show script, but there were several surprises. First Lady Michelle Obama, who joined the ABC telecast from the White House, announced "Argo" as the best picture. And the ceremony featured only the sixth tie in Oscar history and the first since 1994, with the sound editing award split between "Zero Dark Thirty" and "Skyfall." For the first time in Oscar history, six best picture nominees were $100-million blockbusters.


The ceremony was billed as a tribute to music in film, and boasted a number of extravagant musical numbers — including a medley of songs from movie musicals and an appearance by Barbra Streisand, who sang "The Way We Were." The telecast also paid homage to the long running James Bond series, with Adele singing the theme from "Skyfall" and Dame Shirley Bassey performing the theme from 1964's "Goldfinger."


Oscars 2013: Nominee list | Red carpet | Highlights


Jennifer Lawrence, 22, nabbed the lead actress prize for her role as an emotionally unstable widow in "Silver Linings Playbook" — and promptly tripped over her long dress walking up the stairs to accept her statuette. The crowd quickly gave her a standing ovation. "You guys are just standing up because you feel bad that I fell and that's embarrassing," Lawrence said to the applauding crowd at the Dolby Theatre.


The evening's very first award — for supporting actor — was a shocker, with long shot Christoph Waltz winning for his role as bounty hunter Dr. King Schultz in Quentin Tarantino's "Django Unchained" over favored contenders Robert De Niro ("Silver Linings Playbook") and Tommy Lee Jones ("Lincoln"). Waltz, who won the same award three years ago for Tarantino's "Inglourious Basterds," dedicated his prize to his writer-director, who also won the Oscar for original screenplay. "We participated in a hero's journey — the hero being Quentin," Waltz said.


Tarantino pulled off a mild surprise with the screenplay triumph for his slave-revenge tale. He dedicated his award to his eclectic cast of actors. "I actually think if people know my movies 30-50 years from now it's because of the characters I create," Tarantino said.


Anne Hathaway's supporting actress win for her emotionally raw portrayal of a doomed seamstress in "Les Misérables" was hardly as startling. The 30-year-old had been the odds-on favorite to win since the film first screened for members of the Motion Picture Academy in late November. "It came true," she stage-whispered as she picked up her trophy for her performance, the centerpiece of which is the lament "I Dreamed a Dream."


Oscars 2013: Backstage | Quotes | Best & Worst moments


Some of the evening's wins were bittersweet.


The animated feature Oscar was shared by "Brave" directors Mark Andrews and Brenda Chapman, an unusual pairing given that Chapman was fired from the Pixar Animation Studios film and replaced by Andrews in the middle of production. "Making these are a struggle — it's a battle, it's a war," Andrews said backstage. "I was very happy it was him who took my place," Chapman said.


Rhythm & Hues Studios, the company behind "Life of Pi's" visual effects win, recently filed for bankruptcy and laid off hundreds of its employees. As Oscar winner Bill Westenhofer addressed the situation in his acceptance speech, he ran over time and the theme from "Jaws" began to play him off the stage. His microphone was cut off just as he said the words "I urge you all…"


William Goldenberg was a double nominee in the film editing category — he worked on both "Argo" and "Zero Dark Thirty" — and won the prize for Affleck's CIA drama.


"Working at my father's deli, I had to do a million things at one time," Goldenberg said backstage about the best training for his job. "It really does prepare you for the multitasking it takes to be in an editing room."





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'Identity Thief' tops box office with $14 million


NEW YORK (AP) — A week after losing the box office title to Bruce Willis, Melissa McCarthy took it back again.


McCarthy's road trip comedy "Identity Thief" topped the box office in its third week of release on Oscar weekend with $14 million for Universal. 20th Century Fox's "A Good Day to Die Hard," starring Willis, slid to fifth with $10.1 million.


The top 20 movies at U.S. and Canadian theaters Friday through Sunday, followed by distribution studio, gross, number of theater locations, average receipts per location, total gross and number of weeks in release, as compiled Monday by Hollywood.com are:


1. "Identity Thief," Universal, $14,017,085, 3,222 locations, $4,350 average, $93,619,615, three weeks.


2. "Snitch," Lionsgate, $13,167,607, 2,511 locations, $5,244 average, $13,167,607, one week.


3. "Escape From Planet Earth," Weinstein Co., $10,682,037, 3,353 locations, $3,186 average, $34,812,699, two weeks.


4. "Safe Haven," Relativity Media, $10,454,713, 3,223 locations, $3,244 average, $47,916,356, two weeks.


5. "A Good Day to Die Hard," Fox, $10,165,633, 3,555 locations, $2,860 average, $51,967,897, two weeks.


6. "Dark Skies," Weinstein Co., $8,189,166, 2,313 locations, $3,540 average, $8,189,166, one week.


7. "Silver Linings Playbook," Weinstein Co., $5,750,866, 2,012 locations, $2,858 average, $107,176,012, 15 weeks.


8. "Warm Bodies," Lionsgate, $4,825,388, 2,644 locations, $1,825 average, $58,243,441, four weeks.


9. "Beautiful Creatures," Warner Bros., $3,608,333, 2,950 locations, $1,223 average, $16,570,598, two weeks.


10. "Side Effects," Open Road Films, $3,357,039, 2,070 locations, $1,622 average, $25,099,555, three weeks.


11. "Zero Dark Thirty," Sony, $2,230,084, 1,197 locations, $1,863 average, $91,539,075, 10 weeks.


12. "Argo," Warner Bros., $1,827,165, 802 locations, $2,278 average, $129,653,502, 20 weeks.


13. "Hansel and Gretel: Witch Hunters," Paramount, $1,684,532, 1,425 locations, $1,182 average, $52,945,086, five weeks.


14. "Life of Pi," Fox, $1,605,366, 572 locations, $2,807 average, $113,525,126, 14 weeks.


15. "Lincoln," Disney, $1,481,081, 875 locations, $1,693 average, $178,603,571, 16 weeks.


16. "Mama," Universal, $1,173,900, 1,163 locations, $1,009 average, $70,230,570, six weeks.


17. "Quartet," Weinstein Co., $1,125,886, 356 locations, $3,163 average, $8,844,950, seven weeks.


18. "Django Unchained," Weinstein Co., $971,655, 659 locations, $1,474 average, $158,783,430, nine weeks.


19. "Amour," Sony Pictures Classics, $716,186, 328 locations, $2,183 average, $5,147,242, 10 weeks.


20. "Wreck-It Ralph," Disney, $645,870, 402 locations, $1,607 average, $186,676,411, 17 weeks.


___


Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.


___


Online:


http://www.hollywood.com


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Books: Gauging Faces and Bodies in the Botox Age





You never know what a little vanity will do for a person’s health. Some people bloom in their quest for physical improvement, others wither, and a few are completely destroyed. Despite centuries’ worth of efforts to penetrate the complicated thickets where health and beauty intertwine, there is always more to explore, as two new books make clear.




Dr. Eric Finzi, a dermatologist in the Washington area, has produced what may be the first authorized biography of botulinum toxin, the fearsome poison that, bottled into mild-mannered Botox, enhances foreheads everywhere. This little molecule does its good work by paralyzing muscles: In the forehead it inactivates the frown-producing corrugators, while used elsewhere on the head and body it can alleviate migraine headaches, stop problem sweating and ease the spasticity associated with a range of neurological diseases.


But even those who know all about the drug’s physical effects will be intrigued by Dr. Finzi’s narrative, because it turns out that cosmetic Botox may not be all about vanity after all. Research studies, including some by Dr. Finzi, have found that the substance appears to alleviate depression more safely and perhaps more effectively than the usual treatments.


That result at first seems trivial and obvious: If you stop frowning at people, they’ll like you more  and treat you better, and you won’t feel so blue. But the process turns out to be considerably more sophisticated and complicated, because it appears to apply even to people without visible frown lines.


Dr. Finzi calls it “noncosmetic cosmetic surgery” and traces the postulated mechanism to some of the lesser-known work of William James and Charles Darwin. Both thinkers argued that facial expressions are not just the outward manifestations of emotion, but vital links in the unconscious neurological processes that create emotion. In other words, if you cannot smile, you will never be as happy as if you could, and if you cannot frown, you will be unable to experience the full intensity of the negative emotions manifested by frowning, depression included.


This “facial feedback hypothesis” has found some modern confirmation in a study showing that injections of Botox into the forehead seem to inhibit activation of the amygdala, the brain structure thought to regulate all gut-wrenching emotion.


Dr. Finzi expands his narrative with a discussion of the subtleties of common facial expressions, including homage to interested parties like Norman Cousins and his idea that laughter could cure disease.


But the book’s major focus is the frown: Dr. Finzi offers anecdotes suggesting that taming overactive corrugators may save marriages and boost careers, and then, spinning some of the still largely debatable theories linking depression and anger with chronic disease, he postulates that Botox treatments may someday prove to help forestall heart disease and cancer.


That’s quite a set of achievements for one bad little molecule, gram for gram the most potent toxin we know. Dr. Finzi is no stylist, but the momentum of his argument keeps the reader with him for the duration (and undoubtedly quite a few overactive corrugators will be soothed into submission as a result).


The complexities of the face almost pale in comparison with those of the torso, as Abigail C. Saguy makes clear in “What’s Wrong With Fat?” “Once you put down this book you will never hear the word ‘obesity’ the same way again,” she promises, and she is absolutely correct.


Dr. Saguy, a sociologist at U.C.L.A., methodically teases out all the overtones of the loaded words we use to describe big bodies. These bodies are, after all, neither good nor bad, just big.


But “fat” often implies the coexistence of sloth, gluttony and self-indulgence. “Obesity” equals disease to medical professionals, while in the world of public health it is a raging epidemic with substantial global mortality. Those immersed in the conventional ideals of beauty see being overweight as an aesthetic disaster, but others find it sexually irresistible, and to activists “fat” has become a rallying cry, with weight-based discrimination a violation of social justice as deplorable as that stemming from race or gender.


In fact, the concept of bigness has become so laden with overtones good and bad — guilt, blame, fear, anger and desire, among others — that finding a value-free way to describe men and women who are larger than average has become almost impossible. “Heavy,” “plus-size,” “corpulent” and “fleshy” all carry weighty implications in one sphere or another.


Dr. Saguy analyzes it all, and asks why. She winds up paying particular attention to the debate in the medical world over the actual health consequences of being fat: Studies keep confounding the reigning supposition that thin is best with evidence that modestly overweight may be even better. Meanwhile, those who are larger than average are routinely blamed for their size, a phenomenon augmented by deplorably simplistic media coverage (unlike anorexia, interestingly enough, which is remarkably free of the same connotations of personal fault).


Much of Dr. Saguy’s text is academic and requires some determination to penetrate, but she also provides immensely readable nuggets, notably a brief discussion of her experiences attending an annual convention of the National Association to Advance Fat Acceptance, where, seven months pregnant, she underwent a funhouse-mirror body-image transformation worthy of Alice in Wonderland. Like Dr. Finzi’s narrative deficiencies, hers fade into unimportance in the face of fascinating and illuminating material.


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Stocks plunge as Italy appears headed for gridlock









Stocks dropped sharply Monday as investors worriedthat Italy could be seized with political paralysis, stymieing the country's economic reforms and causing another flare-up in the region's debt crisis.

The Dow Jones industrial average plunged 216 points to 13,784, a loss of 1.6 percent and the biggest drop since November.

The Standard & Poor's 500 dropped 27 points, or 1.8 percent, to 1,487. The Nasdaq lost 45 points to 3,116.

An early gain was gone by midday after reports from Italy suggested that the country was headed for political gridlock following strong gains by former premier Silvio Berlusconi and a protest campaign led by a former comedian.

Four stocks fell for every one that rose on the New York Stock Exchange. Volume was average, 3.8 billion shares.

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